NCT07239999

Comparing Spinal Anesthesia With 1% Chloroprocaine Versus 1% Mepivacaine in Patients Undergoing Outpatient Primary Total Knee Arthroplasty

Randomized Controlled Trial Comparing Spinal Anesthesia With 1% Chloroprocaine Versus 1% Mepivacaine in Patients Undergoing Outpatient Primary Total Knee Arthroplasty

• Status: Not Yet Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 170 (estimated)
• Sponsor: Nova Scotia Health Authority · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study or clinical trial looking to compare 2 types of freezing medications injected into the spinal fluid at the lower back between the vertebrae in patients going to have total knee replacement surgery to check for early legs movement, early discharge from recovery room, walking and hospital discharge. This could save hospital cost of such procedures.

Conditions

• Recovery Period
• Anesthesia

Interventions

Type	Name	Description
DRUG	Mepivacaine Injection	Comparing time to motor block recovery in PACU, time to PACU discharge, time to ambulation and length of hospital stay
DRUG	Chloroprocaine Injection	Comparing time to motor block recovery in PACU, time to PACU discharge, time to ambulation and length of hospital stay

Timeline

• Start date: 2026-03-31
• Primary completion: 2027-04-04
• Completion: 2027-06-15
• First posted: 2025-11-20
• Last updated: 2026-02-06