NCT07237958

Effects on the Olfactory Epithelium and the Olfactory Nerve From Exposure to Diesel Exhaust

Effects on the Olfactory Epithelium in the Nose and the Olfactory Nerve (Nervus Olfactorius) From Exposure to Diesel Exhaust

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: Umeå University · Academic / Other
• Sex: All
• Age: 20 Years – 70 Years
• Healthy volunteers: Accepted

Summary

The goal of this study is to study the effect exposure to air pollution and its effect on development of dementia. Does the diesel exhaust change the function of the olfactory system? Have the exposures measurable effects on the sense of smell and cognitive ability? Forty people are exposed to diesel exhaust exhaust and filtered air. The exposures are blinded and in a randomized order. Both groups undergo biopsies of the olfactory epithelium in the nose under local anesthesia after the exposures and after performing cognitive test.

Conditions

• Alzheimer Disease (AD)
• Dementia Alzheimer Type
• Air Pollution Exposure

Interventions

Type	Name	Description
OTHER	Diesel Exhaust Particles	During exposure to diesel exhaust, participants alternate between 15-minute periods of rest and exercise on an ergometer cycle with a workload that results in a minute ventilation of 20L/min/m² body surface area. Symptom recording is done every 30 minutes, following a routine based on a modified Borg scale.
OTHER	Filtered air	During exposure to filtered air, participants alternate between 15-minute periods of rest and exercise on an ergometer cycle with a workload that results in a minute ventilation of 20L/min/m² body surface area. Symptom recording is done every 30 minutes, following a routine based on a modified Borg scale

Timeline

• Start date: 2019-02-01
• Primary completion: 2023-05-12
• Completion: 2023-05-19
• First posted: 2025-11-20
• Last updated: 2025-11-20

Locations

1 site across 1 country: Sweden