NCT07237022

The Role of TRP Channels in DPN

The Role of Transient Receptor Potential Channels in Diabetic Peripheral Neuropathy

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 20 (estimated)
• Sponsor: Universitaire Ziekenhuizen KU Leuven · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The study aims to characterize the vascular response upon topical application of cinnamaldehyde, allyl isothiocyanate and capsaicin on feet skin in healthy volunteers. The vascular response will be characterized in terms of response over time, dose-response, inter-foot and inter-period reproducibility.

Conditions

• Physiological Responses

Interventions

Type	Name	Description
OTHER	Cinnamaldehyde	A 10% and 30% cinnamaldehyde solution is topically applied on foot skin.
OTHER	Allyl isothiocyanate (AITC)	A 15% and up to 30% AITC solution is topically applied on foot skin.
OTHER	Capsaicin	A 1.5% and 5% capsaicin solution is topically applied on foot skin.

Timeline

• Start date: 2025-10-08
• Primary completion: 2026-05-31
• Completion: 2026-08-31
• First posted: 2025-11-19
• Last updated: 2025-11-19

Locations

1 site across 1 country: Belgium