NCT07236671

Progression Patterns of Choroidal Venous Alterations

International Multi-centre, Prospective, Longitudinal Cohort to Evaluate the Progression Pattern of Choroidal Venous Alterations

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 250 (estimated)
• Sponsor: Singapore National Eye Centre · Other Government
• Sex: All
• Age: 45 Years
• Healthy volunteers: Not accepted

Summary

This study is about understanding how a condition called pachychoroid changes over time. Pachychoroid refers to an anatomic choroidal characteristic with abnormally thick choroid or abnormally dilated Haller's vessels. Pachychoroid can range from mild forms which does not cause any problems to more serious ones that might cause vision loss.This study will recruit participants with pachychoroid, to learn more about how this condition develops, how it affects people in the long run, and what factors might make it worse.

Detailed description

This study aims to document the longitudinal progression pattern and the incidence rate of progression of choroidal venous alteration (defined as either an increase in number of quadrants with pachyvessels or formation of new anastomoses which violates the physiological watershed It will provide valuable natural history data to study the pattern of evolution of choroidal vessels over time and validate the proposed multi-hit theory over a period of three years.

Conditions

• Pachychoroid Disease

Timeline

• Start date: 2025-03-04
• Primary completion: 2029-06-01
• Completion: 2029-08-01
• First posted: 2025-11-19
• Last updated: 2025-11-28

Locations

4 sites across 3 countries: Hong Kong, Malaysia, Singapore