NCT07236281

Selenium Levels in Patients With Abdominal Aneurysm

Selenium Levels in Patients With Abdominal Aortic Aneurysm

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 40 (actual)
• Sponsor: Comenius University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Retrospective study comparing the selenium level in patients with abdominal aortic aneurysm with the selenium level in patients in the control group, i.e., patients without aneurysmal changes of the abdominal aorta.

Detailed description

Selenium (Se), incorporated into selenocysteine, is an essential component of selenoproteins. These proteins play a crucial role in vascular protection by reducing oxidative stress, regulating inflammation, supporting endothelial nitric oxide signalling, and maintaining smooth muscle cell homeostasis. Insufficient selenoprotein activity contributes to vascular dysfunction and weakening of the vessel wall. The aim of this project is to investigate a potential association between reduced selenium levels and abdominal aortic aneurysm (AAA) of degenerative origin. The study group will include 20 individuals with an abdominal aortic aneurysm measuring at least 35 millimeters in diameter, verified by a radiologist using standard diagnostic imaging methods (ultrasound, CT angiography, or digital subtraction angiography). The control group will comprise 20 individuals without an abdominal aortic aneurysm. Selenium blood levels will be measured in both groups, and the relationship between selenium status and the presence of AAA will be evaluated using biostatistical analysis.

Conditions

• Abdominal Aneurysm
• Selenium Deficiency

Timeline

• Start date: 2025-01-15
• Primary completion: 2025-09-15
• Completion: 2026-06-30
• First posted: 2025-11-19
• Last updated: 2025-11-19

Locations

1 site across 1 country: Slovakia