NCT07233629

M-TAPA vs RSB in Midline Abdominal Incision Laparotomy

Comparison of the Effects of Modified ThoracoAbdominal Nerve Block Through Perichondrial Approach Versus Rectus Sheath Block on Postoperative Pain in Midline Abdominal Incision Laparotomy

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Cumhuriyet University · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

The aim is to compare the postoperative analgesic effects of Modified ThoracoAbdominal nerve block through Perichondrial Approach (M-TAPA) versus Rectus Sheath Block (RSB) in patients undergoing laparotomy with midline abdominal incision.

Detailed description

Patients were divided into two randomized groups: Group 1 (S-TAP group, n=30) and Group 2 (RSB group, n=30). All patients will receive the same standard general anesthesia per hospital protocol. All blocks will be applied with the same ultrasonography and block equipment, and by the same physician. All patients will receive Paracetamol 1gr and Dexketoprofen 50mg intravenous (IV) 10 minutes prior to skin closure. After the surgery waqs completed, patients in Group 1 will receive modified thoracoabdominal nerve block through perichondrial approach (M-TAPA) with 20 mL of 0.25% bupivacaine bilaterally (with a total volume of 40 mL). Patients in Group 2 will receive rectus sheath block (RSB) with 20 mL of 0.25% bupivacaine bilaterally (with a total volume of 40 mL). Routine analgesic procedure consisting of 3x1gr Paracetamol and 2x50mg Dexketoprofen will be followed postoperatively for 24 hours. Numeric Rating Scale (NRS) will be used to assess postoperative pain on 1st, 6th, 12th, 18th and 24th hours after the surgery. Tramadol 50mg IV will be administered as a rescue analgesic for all patients if NRS score is equal to or higher than 4. Total Tramadol consumption will be calculated.

Conditions

• Postoperative Pain
• Laparotomy

Interventions

Type	Name	Description
PROCEDURE	Modified thoracoabdominal nerve block through perichondrial approach (M-TAPA)	20 mL of 0.25% bupivacaine on each side
PROCEDURE	Rectus Sheath Block	20 mL of 0.25% bupivacaine on each side

Timeline

• Start date: 2023-06-01
• Primary completion: 2025-06-01
• Completion: 2026-02-01
• First posted: 2025-11-18
• Last updated: 2025-11-18

Locations

1 site across 1 country: Turkey (Türkiye)