NCT07231926

Intrathecal Morphine for Recovery and Outcomes After VATS

The Effects of Intrathecal Morphine in Addition to Serratus Anterior Plane Block and Dexmedetomidine on Postoperative Recovery (QoR-15) and Systemic Inflammation in Video-Assisted Thoracoscopic Surgery: A Randomized Controlled Trial

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 52 (estimated)
• Sponsor: Ataturk University · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

This study will compare two different methods of pain management in patients undergoing video-assisted thoracoscopic surgery (VATS). One group will receive a combination of spinal morphine, nerve block, and dexmedetomidine, while the other group will receive a nerve block and dexmedetomidine without spinal morphine. All patients will receive standard pain medications after surgery. The purpose is to see if adding spinal morphine improves pain control and recovery after surgery.

Detailed description

This is a single-center, prospective, randomized, double-blind clinical trial evaluating the efficacy of intrathecal morphine in combination with serratus anterior plane block (SAPB) and dexmedetomidine infusion for postoperative analgesia in patients undergoing elective video-assisted thoracoscopic surgery (VATS). Eligible patients are ASA I-II, aged 18-70 years, with BMI \< 35 kg/m². Patients will be randomized into two groups using a computer-generated sequence. The intervention group will receive intrathecal morphine (200 µg) in addition to SAPB and dexmedetomidine, while the control group will receive SAPB and dexmedetomidine alone. The primary outcome is postoperative pain scores (VAS) within the first 24 hours. Secondary outcomes include opioid consumption, quality of recovery, and incidence of side effects.

Conditions

• Postoperative Pain Management in Video-Assisted Thoracoscopic Surgery

Interventions

Type	Name	Description
DRUG	Intrathecal Morphine	200 µg morphine sulfate, single-dose via L3-L4, 27G Sprotte spinal needle, prior to induction.
PROCEDURE	Serratus Anterior Plane Block (SAPB) group	Ultrasound-guided unilateral SAPB at end of surgery with 30 mL 0.25% bupivacaine.
DRUG	Dexmedetomidine	Loading dose 0.5 µg/kg over 15 minutes, then 0.5 µg/kg/h continuous infusion intraoperatively.

Timeline

• Start date: 2025-12-01
• Primary completion: 2026-06-01
• Completion: 2026-06-02
• First posted: 2025-11-17
• Last updated: 2026-02-05

Locations

2 sites across 1 country: Turkey (Türkiye)