NCT07231484

Effects of Grape Consumption on the Immune-Gut Axis in Obesity

Effects of Grape Consumption on Immune and Gut Health in the Setting of Obesity

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: University of Missouri-Columbia · Academic / Other
• Sex: All
• Age: 30 Years – 45 Years
• Healthy volunteers: Not accepted

Summary

This study is investigating the benefits of whole freeze-dried grape powder consumption on the immune-gut axis in adults with obesity.

Detailed description

The study is a 12-wk randomized, controlled, crossover trial. Participants will be randomized to one of two intervention sequences, either consuming 48g/day of whole freeze-dried grape powder followed by an isocaloric placebo powder or consuming the placebo powder followed by the whole freeze-dried grape powder. Active intervention phases will be 4 weeks in duration followed by a 4-week washout period between treatments.

Conditions

• Obesity &Amp; Overweight

Interventions

Type	Name	Description
OTHER	Freeze-dried grape powder	48 g/day oral consumption during the 4-week active period.
OTHER	Placebo powder	Isocaloric placebo matched to grape powder; oral consumption during the 4-week active period.

Timeline

• Start date: 2025-12-19
• Primary completion: 2027-12-20
• Completion: 2027-12-30
• First posted: 2025-11-17
• Last updated: 2025-12-30

Locations

1 site across 1 country: United States