NCT07231133

Effect of Within-Meal Consumption of Allulose on Diet-induced Thermogenesis

Effect of Within-Meal Consumption of Allulose Compared to Sucralose and Stevia on Diet-induced Thermogenesis, Substrate Oxidation, Glycemic Response, and Satiety in Normal Weight Adults

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: Toronto Metropolitan University · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The objective of this study is to investigate the within-meal effects of allulose compared to sucralose and stevia on diet-induced thermogenesis, substrate oxidation, glycemic response, and subjective appetite in healthy normal weight adults.

Detailed description

A within-subject, repeated measures, randomized, repeated measures design will be used. Participants (n=10, 5 males, 5 females) will consume, in a random order, one of four test treatments on 4 separate days: (1) meal alone, (2) allulose + meal, (3) sucralose + meal or (4) stevia + meal. The allulose, sucralose, and stevia component of the treatment will be matched for sweetness. The dose of allulose will be confirmed in another study that will be completed prior to the start of the present study. The allulose, sucralose and stevia component of the treatment will be consumed 15 minutes prior to the breakfast meal, followed by the meal being consumed within 30 minutes. After treatment consumption, energy expenditure measurements via indirect calorimetry will be collected in 30-min increments (30-min measurement, 30-min rest) for 5 hours. Blood glucose will be measured at baseline and continuously for 5 hours via the Freestyle Libre 2 continuous glucose monitoring system. Subjective appetite (hunger, fullness, desire to eat, prospective food consumption) will be measured via visual analogue scales at baseline and at the end of each energy expenditure measurement over 5 hours.

Conditions

• Diet Induced Thermogenesis

Interventions

Type	Name	Description
OTHER	Allulose	Within meal consumption of Allulose (20 g)
OTHER	Stevia	Within meal consumption of Stevia (0.0481 g). Matched for sweetness with Allulose treatment.
OTHER	Sucralose	Within meal consumption of Sucralose (0.0238 g). Matched for sweetness with Allulose treatment.
OTHER	Meal	Control treatment. Meal consumed alone.

Timeline

• Start date: 2025-05-06
• Primary completion: 2025-08-11
• Completion: 2025-08-11
• First posted: 2025-11-17
• Last updated: 2025-11-17

Locations

1 site across 1 country: Canada