NCT07230600

AD-SVF Therapy for Refractory Endometrial Infertility

Autologous Adipose-derived Stromal Vascular Fraction Therapy for Refractory Endometrial Infertility

• Status: Recruiting
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 10 (estimated)
• Sponsor: The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School · Academic / Other
• Sex: Female
• Age: 22 Years – 45 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to initially explore the efficacy of adipose-derived stromal vascular fraction (AD-SVF) therapy in the treatment of refractory endometrial infertility.

Detailed description

Patients with refractory thin endometrium (endometrial thickness \< 6 mm at late proliferative phase or after high-dose estrogen therapy) and/or moderate to severe intrauterine adhesion are recruited for fertility. After detailed explanation of the treatment plan, written informed consent will be obtained from the patients. The subjects undergo liposuction performed by plastic surgeons to obtain adipose tissue, from which AD-SVF is isolated and extracted for intrauterine infusion therapy. Six months post-AD-SVF treatment, the improvement in menstrual volume and endometrial thickness will be assessed during follow-up visits. The subjects will be advised, based on their personal inclination, to attempt conception (hysteroscopic surgery will be repeated if necessary), and their early pregnancy outcomes will be documented in subsequent follow-ups.

Conditions

• Endometrium; Atrophy
• Intrauterine Synechiae

Interventions

Type	Name	Description
BIOLOGICAL	AD-SVF	AD-SVF is isolated and extracted from adipose tissue for intrauterine infusion therapy.

Timeline

• Start date: 2025-11-01
• Primary completion: 2026-12-01
• Completion: 2027-06-01
• First posted: 2025-11-17
• Last updated: 2025-11-18

Locations

1 site across 1 country: China