NCT07230145

A Trial of SHR-4658 in Healthy Volunteers or Volunteers With Elevated Blood Pressure

A Double-Blind, Randomized, Dose-Escalating Phase I Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single-Dose SHR-4658 in Healthy Volunteers or Volunteers With Elevated Blood Pressure

• Status: Not Yet Recruiting
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 48 (estimated)
• Sponsor: Beijing Suncadia Pharmaceuticals Co., Ltd · Industry
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Accepted

Summary

This is a clinical study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamic and immunogenicity of single subcutaneous injection of SHR-4658 in healthy volunteers and volunteers with elevated blood pressure.

Conditions

• Heart Failure

Interventions

Type	Name	Description
DRUG	SHR-4658 Injection.	SHR-4658 injection.
DRUG	SHR-4658 Placebo Injection	SHR-4658 placebo injection.

Timeline

• Start date: 2025-11-01
• Primary completion: 2026-06-01
• Completion: 2026-07-01
• First posted: 2025-11-17
• Last updated: 2025-11-17

Locations

1 site across 1 country: China