Trials / Recruiting
RecruitingNCT07226076
Methadone in TKA for Post-op Pain and Opioid Reduction
Reduction of Post-op Pain and Opioid Consumption With the Addition of Methadone in Total Knee Arthroplasty: a Double-blind Randomized Control Trial
- Status
- Recruiting
- Phase
- Phase 3
- Study type
- Interventional
- Enrollment
- 162 (estimated)
- Sponsor
- Medical University of South Carolina · Academic / Other
- Sex
- All
- Age
- 18 Years – 75 Years
- Healthy volunteers
- Not accepted
Summary
This randomized, double-blind controlled trial investigates whether intraoperative IV methadone (0.15 mg/kg based on ideal body weight) reduces acute postoperative pain and opioid consumption in patients undergoing elective total knee arthroplasty under spinal anesthesia with mepivacaine.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Methadone Hydrochloride | Patients will intraoperatively be administered methadone 0.15mg/kg IV, based on ideal body weight. |
Timeline
- Start date
- 2026-01-08
- Primary completion
- 2026-12-28
- Completion
- 2027-01-15
- First posted
- 2025-11-10
- Last updated
- 2026-02-04
Locations
1 site across 1 country: United States
Regulatory
- FDA-regulated drug study
Source: ClinicalTrials.gov record NCT07226076. Inclusion in this directory is not an endorsement.