NCT07224659

Exercise and Mortality in Middle-Aged and Older Adults

Exercise and Mortality in Middle-Aged and Older Adults: A Target Trial Emulation

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 19,000 (estimated)
• Sponsor: City of Hope Medical Center · Academic / Other
• Sex: All
• Age: 55 Years – 74 Years
• Healthy volunteers: Not accepted

Summary

This protocol is a retrospective study using the observational data of the the Prostate, Lung, Colorectal, and Ovarian (PLCO) screening trial with over 150,000 participants aged 55-74 years to conduct a target trial emulation to examine the association between self-reported exercise and all cause and cause-specific mortality in apparently healthy, middle-aged and older adults. The PLCO includes assessments of participants' exercise level at two timepoints: at randomization into the PLCO trial (Q0) and 5-7 years after randomization into the PLCO (Q1).

Conditions

• Overall Survival (All-cause Mortality)

Interventions

Type	Name	Description
BEHAVIORAL	Control	0 or less than 1 day per week, with each session, on average \< 15 minutes.
BEHAVIORAL	Exercise	\>/= 2 days per week of moderate or vigorous intensity, with each session, on average, \>/=20 minutes in duration.

Timeline

• Start date: 2026-04-01
• Primary completion: 2026-08-06
• Completion: 2026-08-06
• First posted: 2025-11-05
• Last updated: 2026-02-04

Locations

1 site across 1 country: United States