NCT07217522

Rutgers University Study of the Genetics of Pulmonary Hypertension

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 10,000 (estimated)
• Sponsor: Rutgers, The State University of New Jersey · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The goal of this observational study is to learn more about how genes impact the risk of pulmonary hypertension. Anyone 18 or older living in the US is eligible, and a diagnosis of PH is NOT required. Study participation is online, and it takes about 20 minutes to complete health surveys and request a saliva collection kit sent through US mail. In return, study participants may opt to receive information about their genetic ancestry at no cost.

Detailed description

This is an online research study to learn more about how genes affect the risk of pulmonary hypertension. No office visit is required and in return, participants may receive information about their genetic ancestry for free. Population-based echocardiography surveys show that pulmonary hypertension (PH) affects roughly 2-3 % of community-dwelling adults and becomes more common with age. This study will increase our understanding of the genetic basis of breast cancer, which is a crucial step in drug development to improve current treatment options. The study investigators seek a diverse population because diversity among participants maximizes the usefulness of the data. Participants will use our online study portal to answer questions about their health and provide their DNA via a saliva sample using a pre-paid mailer. Participation takes approximately 20 minutes. Participants will be invited to share data from their electronic health records, but this is not required for study participation. The study investigators keep participants engaged with short monthly newsletters.

Conditions

• Pulmonary Hypertension
• Pulmonary Arterial Hypertension
• Pulmonary Arterial Hypertension (PAH) (WHO Group 1 PH)
• Pulmonary Arterial Hypertension Associated With Connective Tissue Disease
• Pulmonary Arterial Hypertension Associated With Connective Tissue Disease (Disorder)
• Pulmonary Arterial Hypertension Associated With Schistosomiasis (Disorder)
• Pulmonary Arterial Hypertension of Congenital Heart Disease
• Pulmonary Arterial and Chronic Thromboembolic Pulmonary Hypertension

Interventions

Type	Name	Description
GENETIC	Saliva sample	Saliva sample is sent via prepaid US Mail for DNA extraction
OTHER	Health surveys	Health surveys are filled out online in the study portal.

Timeline

• Start date: 2025-08-23
• Primary completion: 2027-12-31
• Completion: 2027-12-31
• First posted: 2025-10-16
• Last updated: 2025-11-03

Locations

1 site across 1 country: United States