NCT07217405

Radiotherapy Compared to Corticosteroid Injection for Treatment of Hand Osteoarthritis

Low-Dose Radiotherapy Compared to Corticosteroid Injection for Treatment of Hand Osteoarthritis

• Status: Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 165 (estimated)
• Sponsor: Mayo Clinic · Academic / Other
• Sex: All
• Age: 50 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this research is to compare low-dose radiotherapy to corticosteroid injection for treatment of hand/wrist osteoarthritis.

Conditions

• Osteoarthritis Hand
• Osteoarthritis Wrist

Interventions

Type	Name	Description
DRUG	Corticosteroid injection (CSI)	A maximum of 3 joints will be treated with standard a standard combination of methylprednisolone and lidocaine: * 1st Carpometacarpal (CMC) joint - 20 mg methylprednisolone/0.5 mL 1% lidocaine\* * Radiocarpal (RC) joint - 40 mg methylprednisolone/1 mL 1% lidocaine\* * Scaphotrapeziotrapezoidal (STT) joint - 20 mg methylprednisolone/0.5 mL 1% lidocaine\* * Metacarpophalangeal (MCP) joint - 20 mg methylprednisolone/0.5 mL 1% lidocaine * Interphalangeal (IP) joint - 10 mg methylprednisolone/0.25 mL 1% lidocaine
RADIATION	Low-dose radiotherapy (LDRT)	Subjects will be treated with low-dose radiotherapy of 300cGy in 6 fractions, 2-3 times per week on non-consecutive days. Non-responders to the initial LDRT treatment will receive a second treatment course of 300cGy in 6 fractions to be given 2-3 times per week on non-consecutive days.

Timeline

• Start date: 2025-12-19
• Primary completion: 2027-05-01
• Completion: 2027-10-01
• First posted: 2025-10-16
• Last updated: 2026-02-13

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study