NCT07215624

Surgical Thromboprophylaxis Practices in Oncology Patients Within the NCORP Network, STOP-VTE Study

Surgical Thromboprophylaxis Practices in Oncology Patients Within the NCORP Network (STOP-VTE)

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 500 (estimated)
• Sponsor: Wake Forest University Health Sciences · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

This study evaluates the use of extended venous thromboembolism prophylaxis (ePPx) following abdominopelvic cancer surgery within the NCI Community Oncology Research Program (NCORP) network, targeting surgeons and surgical advanced practice providers (APPs).

Detailed description

PRIMARY OBJECTIVE: I. To evaluate self-reported utilization of guideline concordant extended venous thromboembolism (VTE) prophylaxis (ePPx) following abdominopelvic cancer surgery within a sample of surgeons practicing within NCORP based on the Part 1 surgeon survey. SECONDARY OBJECTIVES: I. Evaluate site factors (e.g., proportion of publicly insured patients, proportion of Black patients, presence of a medical school, NCI designation) and surgeon factors (e.g., fellowship training, years in practice) associated with surgeon self-reported guideline concordant ePPx utilization (Part 1). II. Conduct semi-structured interviews among a subset of surgeons and surgical APPs to assess: 1) Barriers/facilitators toward ePPx after cancer surgery and 2) Acceptability of clinical decision support tools to support VTE prophylaxis prescribing (Part 2). III. Extract EHR data from select practices to assess the feasibility of query-based electronic health record (EHR) data extraction for identification of (i) patients undergoing cancer surgery, and (ii) prescription of guideline concordant ePPx among eligible patients (Part 3). OUTLINE: This is an observational study. PART 1: Surgeons and APPs complete a survey on study. After completion of surgeon or APP survey, site contact person or Cancer Care Delivery Research (CCDR) lead complete site surveys on study. PART 2: A subset of surgeons and APPs from part 1 complete a semi-structured interview on study. PART 3: Site contact person or CCDR lead complete a survey to identify a EHR Report Specialist on study. EHR Report Specialist performs an EHR Data Extraction and provides feedback on the process in a survey.

Conditions

• Malignant Digestive System Neoplasm
• Malignant Female Reproductive System Neoplasm
• Malignant Genitourinary System Neoplasm

Interventions

Type	Name	Description
OTHER	Non-Interventional Study	Non-interventional study
OTHER	Non-Interventional Study	Non-interventional study
OTHER	Non-Interventional Study	Non-interventional study

Timeline

• Start date: 2026-01-15
• Primary completion: 2026-12-01
• Completion: 2027-06-01
• First posted: 2025-10-10
• Last updated: 2026-04-08

Locations

59 sites across 2 countries: United States, Puerto Rico