NCT07215013

Acoustic Resonance Therapy for Treating Empty Nose Syndrome

Acoustic Resonance Therapy for Treatment of Empty Nose Syndrome: A Prospective, Phase 2 Randomized Clinical Trial

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Stanford University · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

This study is to determine whether Acoustic Resonance Therapy (ART), an FDA-approved treatment for standard nasal obstruction, may be helpful in mitigating the debilitating symptoms of Empty Nose Syndrome (ENS), which includes an alternative form of nasal obstruction. ART is a non-invasive treatment that uses sound vibrations to improve nasal congestion and other sinus symptoms. ART works by delivering specific frequencies of sound to the sinonasal cavities (nose and sinuses). These vibrations cause the tissues in the sinuses to resonate, which can help break up mucus and clear blockages, reduce inflammation, and improve airflow.

Conditions

• Empty Nose Syndrome
• Nasal Obstruction

Interventions

Type	Name	Description
DEVICE	Personalized ART	ART personalized to the patient's exact cranio-facial dimensions. Once dimensions are calculated, ART frequency is calculated by an algorithm that is then transmitted to a headband worn by the patient three times a day.
DEVICE	Non-personalized ART	ART frequency randomly transmitted to a headband worn by the patient three times a day.

Timeline

• Start date: 2028-07-01
• Primary completion: 2030-07-01
• Completion: 2030-07-01
• First posted: 2025-10-10
• Last updated: 2025-10-10

Locations

2 sites across 1 country: United States

Regulatory

• FDA-regulated device study