NCT07213648

Modification of Threat Interpretation Bias to Reduce Anxiety in Neurodegenerative Movement Disorders (Aim 3)

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 136 (estimated)
• Sponsor: University of Virginia · Academic / Other
• Sex: All
• Age: 21 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to assess preliminary efficacy of a tailored cognitive bias modification for interpretation (CBM-I) app for reducing anxiety in Huntington's disease and Parkinson's disease.

Detailed description

The investigators will conduct a pilot randomized controlled trial of the MindTrails-Movement CBM-I app in patients with Huntington's disease and Parkinson's disease (N=136). Participants randomly assigned to the intervention group (N=68) will be asked to download the MindTrails-Movement mobile app and to complete daily CBM-I training sessions and nightly surveys, in addition to surveys at baseline and every 2 weeks for the duration of the 6-week intervention and at 4-week follow-up (week 10). Participants assigned to the waitlist control group will download a control version of the app without CBM-I training sessions. They will be asked to complete surveys in the app at baseline and every 2 weeks for the duration of the 6-week intervention and at 4-week follow-up (week 10). After 10 weeks, they will be offered the opportunity to access the version of MindTrails-Movement with CBM-I training content.

Conditions

• Huntington Disease
• Parkinson Disease

Interventions

Type	Name	Description
BEHAVIORAL	MindTrails-Movement	CBM-I training app with active CBM-I training condition
OTHER	Waitlist Control	Version of MindTrails-Movement app including surveys and list of support resources but without active CBM-I training component

Timeline

• Start date: 2025-11-20
• Primary completion: 2026-08-01
• Completion: 2026-09-01
• First posted: 2025-10-09
• Last updated: 2025-11-21

Locations

1 site across 1 country: United States