NCT07212647

Home-Based Strategies for Knee Osteoarthritis

Home-Based Strategies for Knee Osteoarthritis: Comparative Effectiveness of Exercise and Topical Therapy in a Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 83 (actual)
• Sponsor: Istanbul University - Cerrahpasa · Academic / Other
• Sex: All
• Age: 40 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Knee osteoarthritis (KOA) is a common chronic joint condition leading to pain, functional limitations, and reduced quality of life. This randomized controlled trial aims to evaluate and compare the effectiveness of a structured home-based exercise program versus topical diclofenac sodium therapy in improving pain, functional outcomes, and health-related quality of life among adults with early-stage KOA. The results are intended to provide evidence on the optimal components of home-based conservative management strategies.

Conditions

• Knee Osteoarthritis
• Knee Osteoarthritis (Knee OA)

Interventions

Type	Name	Description
OTHER	Home Exercise Group	Patient education + structured, video-based home exercise program Participants instructed to perform exercises 5 days per week for 6 weeks Adherence monitored via logs and telephone follow-up at week 3
OTHER	Topical Therapy Group	Patient education + 1.5% diclofenac sodium gel Participants applied gel to anterior, medial, and lateral aspects of the knee, once daily, without massage techniques, for 6 weeks

Timeline

• Start date: 2025-10-09
• Primary completion: 2026-02-26
• Completion: 2026-02-26
• First posted: 2025-10-08
• Last updated: 2026-02-27

Locations

2 sites across 1 country: Turkey (Türkiye)