NCT07210749

Radiotherapy 12Gy in 6 Fractions For Orbital Lymphoma

A Phase II Trial Assessing 12 Gy in 6 Fractions Radiotherapy for Low-Grade B-cell Orbital Lymphoma

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 36 (estimated)
• Sponsor: British Columbia Cancer Agency · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Current standard RT doses (24-25Gy) provide excellent disease control for patients with indolent B-cell orbital lymphoma, but can cause significant late toxicities. Ultra-low dose RT (4Gy in 2 fractions) has minimal toxicity but lower disease control, requiring intensive follow-up to salvage persistent tumors. Some centers are moving towards this dose as the new standard. A recent study using 12Gy in 4 fractions to any body site showed early data suggesting high disease control rates with minimal toxicity. This study assesses 12Gy in 6 fractions, aiming to enhance disease control over 4Gy while reducing toxicity compared to 24Gy.

Conditions

• Orbital Lymphoma

Interventions

Type	Name	Description
RADIATION	External Beam Radiation Therapy	12 Gy in 6 fractions of external beam radiation therapy

Timeline

• Start date: 2025-11-01
• Primary completion: 2035-08-31
• Completion: 2036-08-31
• First posted: 2025-10-07
• Last updated: 2025-10-07

Locations

1 site across 1 country: Canada