NCT07210437

Longitudinal Autonomic Characterization as a Predictor for Secondary Medical Complications Post-SCI

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 18 (estimated)
• Sponsor: Mayo Clinic · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this research is to learn about how the body is able to balance changes in blood pressure, how that changes over time, and how these changes impact a participant's risk of developing medical problems.

Conditions

• Spinal Cord Injuries

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Tests of sympathetic inhibition	Bolus phenylephrine infusion using the Oxford technique will generate the need to inhibit sympathetic activity. Similarly, resting state Mayer waves will be assessed with regard to heart rate and blood pressure responses.
DIAGNOSTIC_TEST	Tests of above level sympathetic activation	Cold pressor test of the hand will be used to cause sympathetic activation. Valsalva's maneuver will assess the ability to buffer against blood pressure fall (phase II).
DIAGNOSTIC_TEST	Testing of below level sympathetic activation	Cold pressor test of the foot and bladder pressor response will be tested.

Timeline

• Start date: 2026-01-31
• Primary completion: 2027-12-31
• Completion: 2028-06-01
• First posted: 2025-10-07
• Last updated: 2026-02-17

Locations

1 site across 1 country: United States