NCT07210411

Acute and Chronic Repercussion of Spinal Cord Stimulation After Spinal Cord Injury

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (estimated)
• Sponsor: Mayo Clinic · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

The purpose of this research is to learn about how the participant's body is able to balance changes in blood pressure, and how spinal cord stimulation affects these changes as well as immune \& cardiovascular function in participants with spinal cord injury.

Conditions

• Spinal Cord Injuries

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Tests of sympathetic inhibition	Bolus phenylephrine infusion using the Oxford technique will generate the need to inhibit sympathetic activity. Similarly, resting state Mayer waves will be assessed with regard to heart rate and blood pressure responses.
DIAGNOSTIC_TEST	Tests of above level sympathetic activation	Cold pressor test of the hand will be used to cause sympathetic activation. Valsalva's maneuver will assess the ability to buffer against blood pressure fall (phase II).
DIAGNOSTIC_TEST	Testing of below level sympathetic activation	Cold pressor test of the foot and bladder pressor response (in individuals with SCI) will be tested.
DEVICE	Epidural stimulation	Currently implanted epidural stimulation will be used during diagnostic testing.
DEVICE	Transcutaneous stimulation	Transcutaneous stimulation will be used for participants with spinal cord injury without an implanted stimulator during diagnostic testing.

Timeline

• Start date: 2026-03-05
• Primary completion: 2030-12-31
• Completion: 2031-04-01
• First posted: 2025-10-07
• Last updated: 2026-03-09

Locations

1 site across 1 country: United States