Trials / Not Yet Recruiting
Not Yet RecruitingNCT07208565
Endocrine Dysfunction in Pediatric Wilson's Disease
A Cross-sectional Study of Endocrine Changes in Children With Wilson's Disease at Assiut University Children's Hospital
- Status
- Not Yet Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 30 (estimated)
- Sponsor
- Assiut University · Academic / Other
- Sex
- All
- Age
- 3 Years – 18 Years
- Healthy volunteers
- Not accepted
Summary
This cross-sectional study investigates endocrine changes in children diagnosed with Wilson's disease, aiming to characterize hormonal dysfunctions affecting pituitary, thyroid, adrenal, and gonadal axes.
Detailed description
Wilson's disease (WD) is an inherited copper metabolism disorder leading to copper accumulation in various organs including endocrine glands. While hepatic and neurological effects are well-documented, endocrine manifestations remain insufficiently studied in children. This study will systematically assess hormonal axes-including pituitary, growth hormone, thyroid, adrenal, and gonadal functions-through clinical evaluation, pubertal staging, and biochemical tests. The study aims to measure the prevalence and spectrum of endocrine abnormalities in pediatric WD patients and correlate them with disease severity and therapy. Findings will highlight underrecognized complications that impact growth, puberty, and fertility, contributing to more comprehensive management of WD in children.
Conditions
Timeline
- Start date
- 2026-06-30
- Primary completion
- 2027-11-30
- Completion
- 2027-12-30
- First posted
- 2025-10-06
- Last updated
- 2025-10-06
Source: ClinicalTrials.gov record NCT07208565. Inclusion in this directory is not an endorsement.