NCT07207577

Evaluation of Physiological and Psychological Factors Involved in Exercise Intolerance in Patients With β-TTD

Evaluation of Physiological and Psychological Factors Involved in Exercise Intolerance in Patients With Transfusion-dependent β-thalassemia

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 36 (estimated)
• Sponsor: Centre Hospitalier Metropole Savoie · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The goal of this clinical trial is to compare physical ability of patients with transfusion-dependent β-thalassemia to control subjects. The main question it aims to answer is: is there a difference in power output at first lactate threshold between patients with transfusion-dependent β-thalassemia and control subjects during maximal incremental exercise test. Participants will have to realise differents exams including measurement of body compposition, maximal incremental exercise test, vertical jump, vasoreactivity test, blood sampling, quality of life questionnaires and neuromuscular assessments.

Conditions

• Beta Thalassemia Transfusion Dependent

Interventions

Type	Name	Description
OTHER	Maximal incremental exercise test	Participants will perform a symptom-limited maximal incremental exercise test on a cycle ergometer.

Timeline

• Start date: 2025-09-04
• Primary completion: 2028-10-01
• Completion: 2028-10-01
• First posted: 2025-10-06
• Last updated: 2025-10-06

Locations

1 site across 1 country: France