NCT07203274

The Role of Janus Kinase (JAK) and Voltage-gated Sodium Channels (Nav) on Pain and Itch

The Role of Janus Kinase (JAK) and Voltage-gated Sodium Channels (Nav) on Pain and Itch Sensitivity in Healthy Volunteers

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Aalborg University · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

It is well known that itch and pain have many communalities in terms of pathways and molecules involved. Therefore, it is very important to investi-gate different substances that work against both pain and itching. The substances delgocitinib and lidocaine have both been shown to relieve various types of pain. We therefore assume that these creams will be also able to relieve itching. The purpose of this trial experiment is therefore to investigate the effect of delgocitinib, lidocaine and their combination on experimentally induced itching.

Conditions

• Itchiness

Interventions

Type	Name	Description
DRUG	Delgocitinib cream	Delgocitinib cream
DRUG	lidocaine cream	Lidocaine cream
COMBINATION_PRODUCT	Lidocaine+Delgocitinib	The two cream will me mixed togheter
DRUG	Vehicle (placebo)	Vehicle Cream
OTHER	Histamine Dihydrochloride (HDC)	One drop of histamine will be applied on the selected areas and pierced with a lancet
OTHER	Cowhage (Mucuna Pruriens)	About 30 spicules will be applied on the selected areas and inserted manually

Timeline

• Start date: 2025-12-01
• Primary completion: 2025-12-31
• Completion: 2026-12-31
• First posted: 2025-10-02
• Last updated: 2025-11-21

Locations

1 site across 1 country: Denmark