NCT07202637

Evaluation of the Variation of the Sub-pulmonary Velocity-time Integral to Predict Fluid Responsiveness

Evaluation of the Variation of the Sub-pulmonary Velocity-time Integral to Predict Fluid Responsiveness Prospective Observational Study

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 205 (estimated)
• Sponsor: Hospital Nord · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Fluid administration is the first-line treatment in hypovolemic states in critically ill patients. Prediction of fluid responsiveness is possible with echocardiography by assessing the variation of the sub-aortic velocity-time integral (AoVTI) during a passive leg raising test (PLR) or Mini-fluid challenge. However, VTI-Ao measurement is not feasible in all patients due to poor echogenicity. Validation of new fluid-responsiveness indices may facilitate the evaluation in this patient population. Among the available indices, variation of the sub-pulmonary VTI is a potential criterion.

Conditions

• Fluid Resuscitation
• Fluid Responsiveness Predictability

Interventions

Type	Name	Description
DRUG	Fluid bolus administration	Fluid infusion of 500 mL of a crystalloïd solution is performed for patients with signs of hypovolemia

Timeline

• Start date: 2024-11-07
• Primary completion: 2026-11-01
• Completion: 2027-05-01
• First posted: 2025-10-02
• Last updated: 2025-10-02

Locations

2 sites across 1 country: France