NCT07202481

Chronic Ingestion of Fructooligosaccharide and Psyllium on Intestinal Transit in Women With Functional Constipation: A Randomized Crossover Trial

Effects of Chronic Ingestion of Fructooligosaccharide and Psyllium on Intestinal Transit Time in Women Diagnosed With Functional Constipation: A Randomized, Crossover, Double-Blind Clinical Trial

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 25 (estimated)
• Sponsor: Federal University of Minas Gerais · Academic / Other
• Sex: Female
• Age: 18 Years – 59 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to evaluate the effect of dietary fibers in the treatment of functional constipation in women. It will also assess the potential side effects associated with fiber consumption. The main questions it aims to answer are: * In women with constipation who do not consume adequate dietary fiber, does supplementation help improve bowel function? * Among the fibers studied, is there any hierarchy of effect in the treatment of constipation (i.e., is one more effective than the other)? The researchers will compare the effects of the two dietary fibers against each other and against a control to evaluate their impact. Participants will: * Consume 20 g of fiber daily for 6 days, divided into two doses of 10 g each. * Attend a nuclear medicine visit at the end of each 6-day fiber period to perform scintigraphy. * Keep a daily record of bowel habits and dietary intake.

Conditions

• Constipation - Functional

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Psyllium powder	Psyllium powder: soluble fiber gel forming, provided at 20 g per day (two doses of 10 g each)
DIETARY_SUPPLEMENT	Fructooligosaccharide	Fructooligosaccharide: prebiotic, provided at 20 g per day (two doses of 10 g each)

Timeline

• Start date: 2026-03-14
• Primary completion: 2027-12-01
• Completion: 2027-12-01
• First posted: 2025-10-01
• Last updated: 2026-03-24

Locations

1 site across 1 country: Brazil