NCT07202299

Open-label Randomized Controlled Trial of Two Protocols for Weaning From High Frequency Oscillatory Ventilation in Preterm Neonates With Respiratory Distress Syndrome Admitted in the NICU of Mansoura University Children Hospital

Randomized Controlled Trial of Two Protocols for Weaning From High Frequency Oscillatory Ventilation in Preterm Neonates With Respiratory Distress Syndrome

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 110 (estimated)
• Sponsor: Mansoura University Children Hospital · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Our study is a randomized controlled trial that compares two weaning protocols of preterm infants with respiratory distress syndrome who are ventilated on high frequency oscillatory ventilation in order to establish the best weaning strategy with the least complications possible for this group of patients.

Conditions

• Respiratory Distress Syndrome (Neonatal)

Interventions

Type	Name	Description
OTHER	HFOV weaning protocol 1	weaning preterm neonates with RDS from HFOV directly to CPAP
OTHER	HFOV weaning protocol 2	weaning of preterm neonates with RDS to CMV then to CPAP

Timeline

• Start date: 2025-09-22
• Primary completion: 2027-03-01
• Completion: 2027-09-01
• First posted: 2025-10-01
• Last updated: 2025-10-01

Locations

1 site across 1 country: Egypt