NCT07201883

Chewing Gum vs. Ondansetron as Rescue Treatment for PONV in Female Patients

A Randomized Clinical Trial; Chewing Gum vs. Ondansetron as Rescue Treatment for PONV in Female Patients Undergoing Laparoscopic Surgery at a Single Centre in Lebanon

• Status: Active Not Recruiting
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 90 (estimated)
• Sponsor: Makassed General Hospital · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The proposed randomized clinical trial aims to test and compare the efficacy of chewing gum vs. Intravenous antiemetic ondansetron as rescue treatment for post-operative nausea and vomiting (PONV) among Lebanese female patients undergoing laparoscopic surgery in the post-operative anesthesia care unit (PACU).

Detailed description

Post-operative nausea and vomiting remains a significant complication following general anesthesia, particularly when volatile anesthetics are used. Previous studies, including a multicenter randomized trial conducted in Australia, have explored alternative treatment modalities for PONV. Chewing gum, a non-pharmacological intervention, has shown promise as a potential alternative or adjunct to conventional antiemetics like ondansetron. This study focuses on the Lebanese female population, aged 18 and above, who have undergone laparoscopic surgery under volatile anesthetic-based general anesthesia. This demographic is chosen based on established risk factors for PONV and may offer unique insights into efficacy within this subgroup.

Conditions

• Postoperative Nausea and Vomiting (PONV)

Interventions

Type	Name	Description
DRUG	Ondansetron (Zofran)	4 mg IV push
OTHER	chewing gum	Peppermint sugar free chewing gum
COMBINATION_PRODUCT	Ondansetron + Chewing gum	Ondansetron 4 mg IV push Peppermint sugar free chewing gum

Timeline

• Start date: 2025-08-22
• Primary completion: 2026-02-28
• Completion: 2026-02-28
• First posted: 2025-10-01
• Last updated: 2025-10-01

Locations

1 site across 1 country: Lebanon