NCT07200869

Outcomes of Vaso-occlusive Crisis in Pediatric Sickle Cell Disease

Vaso-occlusive Crisis Incidence and Outcomes in a Pediatric Sickle Cell Population

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 25 (estimated)
• Sponsor: Assiut University · Academic / Other
• Sex: All
• Age: 1 Year – 18 Years
• Healthy volunteers: Not accepted

Summary

This study aims to assess the incidence and clinical outcomes of vaso-occlusive crises in pediatric patients with sickle cell disease. Data will be collected and analyzed to identify risk factors and related complications.

Detailed description

Sickle cell disease is a hereditary blood disorder characterized by the presence of sickle-shaped red blood cells, which leads to recurrent vaso-occlusive crises (VOC). These painful episodes are among the most common causes of hospitalization and are associated with significant morbidity in pediatric patients. Despite ongoing improvements in the management of sickle cell disease, there is still limited data describing the incidence, risk factors, and clinical outcomes of VOC in children within our population. This study is designed to retrospectively analyze medical records of pediatric patients with sickle cell disease at Faculty of Medicine, Assiut University. The primary aim is to estimate the incidence of vaso-occlusive crises and to identify the most frequent complications. Secondary objectives include evaluating treatment approaches, length of hospital stay, and clinical outcomes. Findings from this study are expected to provide valuable insights that may help improve clinical care strategies and preventive measures for affected children.

Conditions

• Sickle Cell Disease
• Vaso-occlusive Crisis

Interventions

Type	Name	Description
OTHER	No intervention	retrospective observational study. No intervention will be administered; data will be collected from existing medical records of pediatric sickle cell patients at Assiut University Hospital.

Timeline

• Start date: 2025-10-01
• Primary completion: 2027-10-01
• Completion: 2027-11-01
• First posted: 2025-10-01
• Last updated: 2025-10-01

Locations

1 site across 1 country: Egypt