NCT07200349

Clinical Evaluation of Local Calcitriol Delivery on Maxillary Canine Retraction

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 22 (estimated)
• Sponsor: Al-Azhar University · Academic / Other
• Sex: All
• Age: 13 Years – 35 Years
• Healthy volunteers: Accepted

Summary

This study will evaluate the effect of locally applied Calcitriol on dental and skeletal changes during upper canine retraction. It is a split-mouth randomized clinical trial, where Calcitriol will be locally applied on one side of the maxilla, and the other side will serve as control.

Detailed description

Orthodontic tooth movement depends on bone remodeling. This study investigates if Calcitriol, the active form of vitamin D3, can affect this process when applied locally during upper canine retraction. The study is designed as a split-mouth randomized clinical trial. Patients needing maxillary first premolar extraction will be included. Calcitriol will be locally applied on one side, and the other will serve as a control. The study will evaluate dental and skeletal changes to see if Calcitriol improves treatment outcomes.

Conditions

• Maxillary Canine Retraction
• Local Calcitriol Delivery
• Orthodontic Tooth Movement

Interventions

Type	Name	Description
DRUG	Calcitriol Delivery	Local delivery of Calcitriol (active form of vitamin D3) to one side of the maxillary canine area during orthodontic treatment. The aim is to assess its effect on dental and skeletal changes during canine retraction in a split-mouth design.

Timeline

• Start date: 2025-11-01
• Primary completion: 2026-09-01
• Completion: 2026-10-01
• First posted: 2025-10-01
• Last updated: 2025-10-01