NCT07200284

Periodontal Air-Polishing Device Versus Manual Scaling and Root Planing

Periodontal Air-Polishing Device Reduces Tissue Damage and Improves Clinical Outcomes and Exosomal Modulation. A Randomized Clinical Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 36 (actual)
• Sponsor: Universidad de Granada · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study looks at two common ways to perform deep cleaning of the gums in people with periodontitis: Airflow® (a spray system that uses fine powder and water) and hand scaling (cleaning with metal instruments). The investigators want to see how each treatment affects inflammation at the molecular level by measuring exosomes (tiny particles released by cells that carry signals) and cytokines (proteins that help regulate inflammation) in the fluid around the gums. Participants will receive one of the two standard treatments and will have samples taken from the mouth (saliva and/or gum fluid) at specific times before and after treatment. The authors will also record clinical measurements such as bleeding, gum pocket depth, and attachment loss, as well as simple questionnaires about symptoms.

Conditions

• Periodontitis

Interventions

Type	Name	Description
PROCEDURE	Airpolishing device	The authors will assess biochemical and clinical variables
PROCEDURE	Manual SRP	Gold standard

Timeline

• Start date: 2025-02-01
• Primary completion: 2025-07-01
• Completion: 2025-08-11
• First posted: 2025-10-01
• Last updated: 2025-10-01

Locations

1 site across 1 country: Spain