NCT07200063

Children Acceptance of AgNP Mouthwash Against Chlorhexidine Mouthwash

Comparative Assessment of Children's Acceptance and Compliance of Mouthwash Containing Silver Nanoparticles Compared to Chlorhexidine Mouthwash: A Randomized Clinical Trial.

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Cairo University · Academic / Other
• Sex: All
• Age: 6 Years – 12 Years
• Healthy volunteers: Accepted

Summary

This study aims to evaluate and compare the children's acceptance of mouthwash containing silver nanoparticles versus Chlorhexidine.

Detailed description

Effective management of dental plaque is crucial for preventing periodontal diseases, dental caries, and other oral health complications. Oral hygiene can be maintained through both chemical and mechanical methods. Chemical methods are particularly beneficial in situations where mechanical cleaning proves challenging. Mouthwashes represent a significant chemical strategy for controlling plaque. Among different types of mouthwashes, chlorhexidine is considered the gold standard due to its high efficacy against a broad spectrum of bacteria and its role in plaque management, which helps prevent periodontal diseases. However, it is important to note that chlorhexidine has several side effects, such as numbness, changes in taste perception, dental staining, and an unpleasant bitter taste. In modern applications, nanotechnology is being utilized more frequently, especially with the integration of nanoparticle materials. Silver nanoparticles, in particular, are widely used in the medical field because of their remarkable antibacterial effects on oral biofilms associated with periodontal disease. Therefore, this research aims to evaluate the children's acceptance of chlorhexidine mouthwash in children compared to a mouthwash containing silver nanoparticles, as well as to assess their respective impacts on gingivitis.

Conditions

• Teeth Staining
• Numbness of the Tongue and Soft Tissue
• Bitter Taste

Interventions

Type	Name	Description
OTHER	nano silver mouthwash	nano silver mouthwash will reduce the side effect of chlorhexidine and increase acceptance of the mouthwash to patients
OTHER	Chlorhexidine mouthwash (0.12%)	the concentration of chlorhexidine
OTHER	Chlorhexidine mouthwash (0.2%)	chlorhexidine mouthwash 0.2% (orovex )

Timeline

• Start date: 2026-01-01
• Primary completion: 2026-03-01
• Completion: 2026-06-01
• First posted: 2025-09-30
• Last updated: 2025-09-30