NCT07198945

Six Versus Twelve Month Index Follow-up After Large Colon Polyp Resection

Six Versus Twelve Month SurveillAnce Following Resection of Nonpedunculated ColorectaL Polyps 20-50 mm IN Size Without High Grade Dysplasia (HGD)

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 546 (estimated)
• Sponsor: Indiana University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The study will compare the use of a 6-month follow-up vs a 12-month follow-up after the removal of a large non-pedunculated polyp 20-50mm in size and without high grade dysplasia.

Conditions

• Colon Cancer
• Colon Polyp
• Adenoma
• Serrated Polyp
• Recurrence, Local Neoplasm
• Endoscopic Resection

Interventions

Type	Name	Description
PROCEDURE	6-month follow-up	Eligible patients randomized to the 6-month follow-up arm will undergo their first surveillance procedure 6 months after the removal of their large polyp to check for recurrent polyp tissue.
PROCEDURE	12-month follow-up	Eligible patients randomized to the 12-month follow-up arm will undergo their first surveillance procedure 12 months after the removal of their large polyp to check for recurrent polyp tissue.

Timeline

• Start date: 2026-02-01
• Primary completion: 2029-08-01
• Completion: 2029-10-01
• First posted: 2025-09-30
• Last updated: 2026-02-04

Locations

1 site across 1 country: United States