NCT07197723

Study of How People Make Decisions About Prostate Cancer Risk

Effect of Polygenic Risk Modifiers on Decisions of BRCA1/2 Mutation Carriers at Risk for Prostate Cancer

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 150 (estimated)
• Sponsor: Memorial Sloan Kettering Cancer Center · Academic / Other
• Sex: Male
• Age: 45 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to learn how people with BRCA1/2 mutations respond to genetic risk modifier testing. The researchers will learn more about how people make choices about their health care, including about methods to screen for prostate cancer. Researchers are also doing this study to learn about how the genetic risk modifier test affects people's thoughts and feelings.

Conditions

• BRCA1/2
• Geneitic Testing

Interventions

Type	Name	Description
GENETIC	cheek (buccal) swab	swab sample in person or at home with a mailed test kit and will fill out a survey
OTHER	Assessments	about 1 week, 6 months, and 12 months after getting the updated cancer risk assessment to complete additional surveys.
OTHER	optional collection of blood	for research testing

Timeline

• Start date: 2025-09-25
• Primary completion: 2027-09-01
• Completion: 2027-09-01
• First posted: 2025-09-29
• Last updated: 2026-03-24

Locations

1 site across 1 country: United States