NCT07195370

Testing YAG Laser Iridotomy for Primary Angle-Closure Glaucoma

Evaluation of the Effectiveness of YAG Laser Iridotomy in Patients With Primary Angle-Closure: Temporal Peripheral Iridotomy Compared to Inferior Peripheral Iridotomy

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 150 (estimated)
• Sponsor: Isfahan University of Medical Sciences · Academic / Other
• Sex: All
• Age: 24 Years
• Healthy volunteers: Not accepted

Summary

This study evaluates the effectiveness and safety of YAG laser peripheral iridotomy performed at two different locations (temporal and inferior) in patients with primary angle-closure glaucoma, a leading cause of blindness worldwide. Patients visiting the glaucoma clinic at Feiz Hospital who are candidates for peripheral iridotomy will participate. In each patient, one eye will receive a temporal iridotomy, and the other eye will receive an inferior iridotomy, with patients unaware of the location used in each eye. The study will measure outcomes such as laser power, intraocular pressure, visual symptoms, and complications over six months to determine which approach is more effective and safer.

Conditions

• Glaucoma Eye
• Angle Closure Glaucoma

Interventions

Type	Name	Description
OTHER	peripheral iridotomy	This procedure involves using a neodymium-doped yttrium aluminum garnet (YAG) laser to create a small hole in the temporal region of the iris in one eye. It aims to relieve intraocular pressure in patients with primary angle-closure glaucoma by improving the flow of aqueous humor. The procedure is performed under local anesthesia in a clinical setting, with patients unaware of which eye receives this treatment. Outcomes, including laser power, intraocular pressure, visual symptoms, and complications, are monitored over six months.

Timeline

• Start date: 2025-05-01
• Primary completion: 2025-10-01
• Completion: 2026-01-01
• First posted: 2025-09-26
• Last updated: 2025-09-26

Locations

1 site across 1 country: Iran