NCT07195084

To Explore the Safety and Efficacy of Hypervision Proton Surgery for Early-stage Non-small Cell Lung Cancer

A Phase I Clinical Study to Explore the Safety and Efficacy of Hypervision Proton Surgery (HyPROS) for Early-stage Non-small Cell Lung Cancer

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (estimated)
• Sponsor: Anhui Provincial Cancer Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study was a single-center, single-arm clinical study to evaluate the safety and efficacy of hypervision proton surgery with single large fractionated doses (34GyE and 39GyE) in the treatment of early peripheral NSCLC.

Detailed description

This study adopted a dose escalation protocol (an improved "two-stage two-dose group" design) to explore the safety and efficacy of visual proton surgery (single large fractionated doses of 34GyE and 39GyE) in the treatment of early peripheral NSCLC.

Conditions

• Non-Small Cell Lung Cancer

Interventions

Type	Name	Description
RADIATION	Hypervision proton surgery	Proton radiaotherapy (34GyE or 39GyE)

Timeline

• Start date: 2025-09-20
• Primary completion: 2027-09-19
• Completion: 2028-09-19
• First posted: 2025-09-26
• Last updated: 2026-04-13

Locations

1 site across 1 country: China