NCT07193836

Synergistic Effect of Intravenous Lidocaine on Anesthetic Induction and Emergence in Patients Undergoing Laparoscopic Cholecystectomy or Gynecological Surgery

• Status: Enrolling By Invitation
• Phase: N/A
• Study type: Interventional
• Enrollment: 195 (estimated)
• Sponsor: General Hospital of Ningxia Medical University · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

This study aims to evaluate the effect of intravenous lidocaine on consciousness changes during anesthesia in patients undergoing laparoscopic cholecystectomy or gynecologic surgery. A total of 150 patients will be randomly assigned to one of three groups: a single-dose lidocaine group, a continuous-infusion group, or a placebo group. All patients will receive standard anesthesia care, and the study will monitor brain activity using EEG-based PSi values to measure anesthesia induction time, recovery time, and changes in consciousness. The goal is to determine whether lidocaine can reduce the amount of anesthetic used, shorten the time to fall asleep, and promote faster awakening after surgery. The results may help improve anesthesia safety and enhance recovery in surgical patients.

Conditions

• Cholecystectomy, Laparoscopic
• Gynecologic Surgical Procedures
• Anesthesia and Procedure Related Time Intervals

Interventions

Type	Name	Description
DRUG	Normal Saline (0.9% NaCl)	Participants in the control group received a single intravenous injection of 0.9% normal saline at induction of anesthesia.
DRUG	Lidocaine	Participants in this group received a single intravenous bolus of lidocaine (1.5 mg/kg) at anesthesia induction. No additional lidocaine was administered thereafter.
DRUG	Lidocaine Bolus + Infusion	Participants in this group received a bolus of lidocaine (1.5 mg/kg) at induction followed by continuous intravenous infusion of lidocaine (2 mg/kg/h) until the end of surgery.

Timeline

• Start date: 2025-09-25
• Primary completion: 2025-12-31
• Completion: 2025-12-31
• First posted: 2025-09-26
• Last updated: 2025-09-26

Locations

1 site across 1 country: China