NCT07192744

Rotigaptide in Endothelial Dysfunction?

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: University of Edinburgh · Academic / Other
• Sex: Male
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Arterial occlusion can lead to tissue ischemia and, if prolonged, end organ infarction. Clinical and experimental data would suggest that restoration of blood flow might trigger additional injury beyond that induced by the ischemia alone, so called Ischemia Reperfusion (IR) injury. IR injury impairs endothelial function through a mechanism that may involve intercellular gap junctions. Rotigaptide (ZP-123) is an anti-arrhythmic drug promoting intercellular coupling by increasing gap junction conductance. We intend to test the hypothesis that rotigaptide protects the forearm arterial circulation from IR-induced endothelial dysfunction.

Conditions

• Ischaemic Heart Diseases

Interventions

Type	Name	Description
PROCEDURE	Forearm vascular study	Forearm blood flow measured by venous occlusion plethysmography during interarterial infusion of vasodilators (Ach). Venous blood sampling via cannula in antecubital fossa.

Timeline

• Start date: 2008-09-19
• Primary completion: 2009-12-31
• Completion: 2009-12-31
• First posted: 2025-09-25
• Last updated: 2025-09-25

Locations

1 site across 1 country: United Kingdom