NCT07191353

Resistance Training and Rapamycin to Enhance Bone Formation in Postmenopausal Women

• Status: Recruiting
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 148 (estimated)
• Sponsor: Odense University Hospital · Academic / Other
• Sex: Female
• Age: 60 Years – 75 Years
• Healthy volunteers: Accepted

Summary

The aim of the present clinical trial is to examine the effects of everolimus, resistance training, or their combination on bone and muscle health formation in elderly women aged 60-75 years. The main questions it aims to answer are: Can rapamycin's analog (Everolimus), resistance training, or their combination, enhance bone formation and muscle functions in elderly women compared to non-treatment controls. Participants will be randomized 1:1:1:1 to one of the following treatment regimens: * Oral everolimus 5 mg once a week. * Oral placebo once a week. * Oral everolimus 5 mg once a week plus resistance training RT 1 hour, 3 times weekly. * Oral placebo once a week plus resistance training RT 1 hour, 3 times weekly. During the study there will be a total of 5-7 visits, where the participants will undergo the following: * Blood samles * DXA-, HRpQCT- (only Odense Universitetshospital) and MRI-scans * Muscle- and bone biopsies * Quality of life questionnaires * Testing of muscle funtion * Metabolic studies of muscle and bone protein turnover using labelling with deuturated water

Conditions

• Healthy
• Osteopenia
• Osteoporosis Risk

Interventions

Type	Name	Description
DRUG	Everolimus	Everolimus 5 mg administered once weekly for 24 weeks
DRUG	Placebo	Placebo administered once weekly for 24 weeks
OTHER	Resistance training	Resistance training 3 times a week for 24 weeks

Timeline

• Start date: 2025-10-20
• Primary completion: 2027-03-01
• Completion: 2027-03-01
• First posted: 2025-09-24
• Last updated: 2026-04-06

Locations

2 sites across 1 country: Denmark