NCT07191275

Study on the Effect of Transcranial Magnetic Stimulation on the Perception of Emotional Images

The Effect of TMS on Emotional Valence Evaluation of Aversive Pictures

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 33 (estimated)
• Sponsor: Prof. Dominique de Quervain, MD · Academic / Other
• Sex: All
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

The goal of the current clinical trial is to investigate whether transcranial magnetic stimulation (TMS) over specific brain areas can influence the perception of emotional images and emotional memory. TMS is a non-invasive superficial brain stimulation generated by a magnetic field. The results of the study aim to provide valuable insights for the use of TMS in the investigation of mental processes.

Conditions

• Emotional Memory

Interventions

Type	Name	Description
DEVICE	Experimental continuous 30 Hz thetaburst transcranial magnetic stimulation	Bilateral continuous theta burst stimulation (cTBS) 30 Hz to the temporo-occipital cortex * Frequency: trains of 30 Hz (3 pulses) every 167 ms (frequency of 6 Hz, in the range of theta band) * Intensity: 100% of resting motor threshold (rMT) * Location: consecutively on left and right temporo-occipital cortex (MNI: -47, -77, 4; 50, -69, -4) * Duration: 33.3 seconds for each side * Timing: Immediately before showing IAPS pictures (off-line)
DEVICE	Control continuous 30 Hz thetaburst transcranial magnetic stimulation	Active control condition using bilateral continuous theta burst stimulation (cTBS) 30 Hz to the superior parietal cortex * Frequency: trains of 30 Hz (3 pulses) every 167 ms (frequency of 6 Hz, in the range of theta band) * Intensity: 100% of resting motor threshold (rMT) * Location: consecutively on left and right superior parietal cortex (MNI: -17, -70, 60; 17, -70, 60) * Duration: 33.3 seconds * Timing: Immediately before showing IAPS pictures (off-line)

Timeline

• Start date: 2025-11-01
• Primary completion: 2026-10-01
• Completion: 2026-10-01
• First posted: 2025-09-24
• Last updated: 2025-11-21

Locations

1 site across 1 country: Switzerland