NCT07190079

Saline Contrast Electrical Impedance Tomography Method for Diagnosis of Acute Pulmonary Embolism

A Multicenter Comparative Study of Saline Contrast Electrical Impedance Tomography Method Versus CTPA in the Diagnosis of Acute Pulmonary Embolism

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 343 (estimated)
• Sponsor: Peking Union Medical College Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of this observational study is to compare the consistency of saline contrast Electrical Impedance Tomography(EIT) method and Computed Tomography Pulmonary Angiography (CTPA) in diagnosing acute pulmonary embolism. The main question it aims to answer is: Can bedside saline contrast EIT method be used for the diagnosis of acute pulmonary embolism? The participants will undergo saline contrast EIT and CTPA examinations successively within 24 hours.

Conditions

• Acute Pulmonary Embolism

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Saline contrast Electrical Impedance Tomography method	This study will enroll patients with clinically suspected or confirmed acute pulmonary embolism (PE) presenting with acute respiratory failure, who undergo electrical impedance tomography (EIT) with saline contrast within 24 hours before or after computed tomography pulmonary angiography (CTPA). The EIT procedure is performed as follows: 1. Breath-Hold Maneuver: (1)Spontaneous breathing patients: Supine position, instructed to hold expiration for ≥8 seconds. (2)Mechanically ventilated patients: Expiratory hold (\>8 sec) achieved via ventilator; deeper sedation will be applied when feasible to prolong breath-hold. 2. Venous Access: (1)Preferred: Central venous catheter (internal jugular or subclavian vein).(2)Alternative: Peripheral forearm vein (preferably the median cubital vein). 3. Contrast Administration:(1)Central venous route: 10 mL of 10% NaCl.(2)Peripheral venous route: 15 mL of 5% NaHCO₃.
DIAGNOSTIC_TEST	Computed Tomography Pulmonary Angiography (CTPA)	Patients who meet the inclusion criteria will undergo CTPA examination using conventional clinical diagnostic methods.

Timeline

• Start date: 2025-09-24
• Primary completion: 2027-05-01
• Completion: 2027-09-15
• First posted: 2025-09-24
• Last updated: 2025-10-02

Locations

1 site across 1 country: China