Trials / Completed
CompletedNCT07188727
Comparative Outcomes of Ulcerative Colitis Patients With Mayo Endoscopic Score 1 and Histologic Activity Versus Mayo Endoscopic Score 2
Refining Clinical Practice in Ulcerative Colitis: The Prognostic Value of Histologic Remission - A Monocentric Retrospective Study
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 159 (actual)
- Sponsor
- IRCCS San Raffaele · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
This retrospective study examines patients with ulcerative colitis who initiated advanced therapy for their disease. In clinical practice, patients with only mild inflammation on endoscopy (Mayo Endoscopic Subscore 1, or MES1) often do not undergo treatment optimization or therapy change. We stratified these patients based on histologic findings from biopsy samples and compared them with patients who had greater endoscopic activity (MES2). We evaluated long-term outcomes, including surgery and hospitalization, to determine whether current management strategies for patients with mild endoscopic disease should be reconsidered.
Conditions
Timeline
- Start date
- 2019-09-01
- Primary completion
- 2025-05-01
- Completion
- 2025-05-01
- First posted
- 2025-09-23
- Last updated
- 2025-09-23
Locations
1 site across 1 country: Italy
Source: ClinicalTrials.gov record NCT07188727. Inclusion in this directory is not an endorsement.