NCT07188389

Immunometabolism of Exercise

Immunometabolism of Exercise and Fitness

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 102 (actual)
• Sponsor: University of Houston · Academic / Other
• Sex: All
• Age: 20 Years – 40 Years
• Healthy volunteers: Accepted

Summary

This study aims to examine the effects of acute aerobic exercise and cardiorespiratory fitness on cellular metabolism of CD8+ T cells and regulatory T cells (Tregs) found in the peripheral blood of humans. In addition, the study will investigate whether the effects of exercise differ based on exercise intensity, as well as whether the effects of exercise and fitness differ between subpopulations of CD8+ T cells and Tregs. Finally, the study aims to examine whether exercise- and fitness-induced changes in cell metabolism relate to changes in cell function.

Conditions

• Cardiorespiratory Fitness and Acute Exercise

Interventions

Type	Name	Description
BEHAVIORAL	Acute exercise-moderate intensity	30 minutes of cycling exercise at moderate (90% of first ventilatory threshold)
BEHAVIORAL	Acute effects-heavy intensity	Participants will cycle 30 minutes at heavy (110% of first ventilatory threshold) intensity

Timeline

• Start date: 2024-03-01
• Primary completion: 2025-04-02
• Completion: 2025-04-03
• First posted: 2025-09-23
• Last updated: 2025-09-23

Locations

1 site across 1 country: United States