NCT07182643

Biomarkers in the Endometrial Fluid, Tissue, and Follicular Fluid of Moderate/Severe Endometriosis Patients

An Exploratory Study of Biomarkers in the Endometrial Fluid, Tissue, and Follicular Fluid of Moderate/Severe Endometriosis Patients: a Prospective Study

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 90 (estimated)
• Sponsor: Region Stockholm · Other Government
• Sex: Female
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

This study aims to explore biomarkers in the endometrial fluid and tissue of women with moderate to severe endometriosis, with a specific focus on those involved in pre-receptive endometrium and embryo implantation. This research has the potential to uncover diagnostic indicators of impaired pre-receptive endometrium, examine pathophysiological pathways, and identify future targets for therapeutic intervention. Ultimately, the findings may contribute to more personalized fertility treatments, offering new hope for women struggling with endometriosis-related infertility.

Conditions

• Endometriosis

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Endometrial fluid	Endometrial fluid collection in the day of OPU
DIAGNOSTIC_TEST	Endometrial biopsy	Endometrial biopsy on the OPU day, Pipelle
DIAGNOSTIC_TEST	Follicular fluid	Follicular fluid sampling on the OPU day

Timeline

• Start date: 2025-10-01
• Primary completion: 2027-12-31
• Completion: 2027-12-31
• First posted: 2025-09-19
• Last updated: 2025-09-19

Locations

1 site across 1 country: Sweden