NCT07181785

Molecular Characterization and Outcomes of Aggressive B-Cell Lymphomas.

Single-center, Retrospective Study Aimed to Perform a Molecular Characterization of Aggressive B-cell Lymphomas (Diffuse Large B-cell Lymphoma, High-grade B-cell Lymphoma With MYC and BCL2 and/or BCL6 Translocations, High-grade B-cell Lymphoma Not Otherwise Specified) and to Observe the Clinical Patients' Outcomes According to the 2017 WHO Classification

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 555 (actual)
• Sponsor: Andrés José Maria Ferreri · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This is a retrospective analysis of the presence of chromosomal rearrangements involving MYC, BCL2 and BCL6 genes by FISH in a retrospective, single-center series of large B-cell lymphomas, in order to allow a better classifications of these cases according to the current WHO 2017 classification. If this evaluation will be confirmed as a reliable method to reclassify in different groups the evaluated tumors, it can be subsequently routinely apply to indicate the best treatment approaches in this high-risk setting of patients with a significant impact on patients' morbidity and mortality, and also on the health system and related costs.

Conditions

• Diffuse Large B Cell Lymphoma (DLBCL)

Interventions

Type	Name	Description
COMBINATION_PRODUCT	Treatments: anthracycline-based combinations followed or not by involved-field radiotherapy	Anthracycline-based combinations followed or not by involved-field radiotherapy

Timeline

• Start date: 2022-07-12
• Primary completion: 2023-07-12
• Completion: 2023-07-12
• First posted: 2025-09-18
• Last updated: 2025-09-18

Locations

1 site across 1 country: Italy