NCT07181265

Drug-Drug Interaction of JMKX003142 With Amiodarone and Febuxostat in Healthy Subjects

A Single-center, Non-randomized, Open-label, Self-controlled Phase I Drug-drug Interaction Clinical Study to Evaluate the Pharmacokinetics of JMKX003142 With Amiodarone, and Febuxostat in Chinese Healthy Subjects

• Status: Not Yet Recruiting
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 48 (estimated)
• Sponsor: Jemincare · Industry
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

This is a open-label, non-randomized, multiple oral dosings, three-period, drug-drug interaction study of JMKX003142 tablet, Amiodarone Hydrochloride Tablets and Febuxostat Tablets in Chinese healthy adult subjects

Conditions

• Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Interventions

Type	Name	Description
DRUG	Amiodarone Hydrochloride Tablets	Cohort 1: The intervention is for study of drug drug interaction of JMKX003142 when administered with Amiodarone
DRUG	Febuxostat Tablets	Cohort 2: The intervention is for study of drug drug interaction of JMKX003142 when administered with Febuxostat Tablets

Timeline

• Start date: 2025-10-30
• Primary completion: 2026-04-30
• Completion: 2026-06-30
• First posted: 2025-09-18
• Last updated: 2025-09-18