NCT07180940

Comparison of Perineural Dexamethasone Versus Dexmedetomidine as Adjuvants to Erector Spinae Plane Block in Lumbar Spine Surgery: A Randomized, Double-blind, Controlled Trial

• Status: Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 150 (estimated)
• Sponsor: Poznan University of Medical Sciences · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This clinical study aims to determine which of two medications-dexamethasone or dexmedetomidine-works better and is safer when used together with a local anesthetic (ropivacaine) in a type of nerve block called the erector spinae plane block (ESPB). This block helps reduce pain after lumbar spine surgery.

Detailed description

All participants will receive general anesthesia for surgery and, in addition, a nerve block on both sides of the lower back. The nerve block will be done with ultrasound guidance and will include ropivacaine plus either dexamethasone or dexmedetomidine. Patients will be randomly assigned to one of these two groups, and neither the patient nor the doctors checking pain after surgery will know which medication was used. The main goal is to see how much opioid pain medicine patients need during the first 24 and 48 hours after surgery. Other things we will look at include how strong the pain is, how soon pain relief is necessary, if there are any side effects like nausea or low blood pressure, and if there are any complications related to the block. This study will help doctors choose the best option to manage pain after spine surgery while reducing the need for opioids and their side effects.

Conditions

• Spine Disease
• Spinal Diseases

Interventions

Type	Name	Description
DRUG	0.9%NaCl	2 x 20ml 0.2% ropivacaine with 2ml of 0.9% NaCl
DRUG	Dexamethasone 4mg	2 x 20ml 0.2% ropivacaine with 2mg of dexamethasone
DRUG	Dexmedetomidine	2 x 20ml 0.2% ropivacaine with 25ug Dexmedetomidine

Timeline

• Start date: 2025-09-01
• Primary completion: 2026-09-30
• Completion: 2026-12-31
• First posted: 2025-09-18
• Last updated: 2025-09-18

Locations

1 site across 1 country: Poland