NCT07180849

Comparing the Antiplaque Effects of Novel Titania Nanoparticle Infused Fluoride Varnish vs Conventional Fluoride Varnish in Fixed Orthodontic Patients.

Comparing the Antiplaque Efficacy of Titania Nanoparticle Infused Fluoride Varnish vs Conventional Fluoride Varnish in Fixed Orthodontic Patients-A Triple Blind Randomised Controlled Trial.

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Pakistan Institute of Medical Sciences · Other Government
• Sex: All
• Age: 16 Years – 30 Years
• Healthy volunteers: Accepted

Summary

In this study the investigators aimed to explore the antibiofilm effect of fluoride varnish loaded with titania nanoparticles synthesized from moringa oleifera leaves extract vs conventional fluoride varnish in multibracket fixed orthodontic patients.

Conditions

• Dental Plaque Accumulation
• Nanoparticles
• Fluoride Varnishes

Interventions

Type	Name	Description
PROCEDURE	Fluoride varnish	Group A will receive conventional fluoride varnish for antiplaque effects.Plaque will be assessed quantitatively by modified plaque index.
PROCEDURE	Novel titania nanoparticle infused fluoride varnish	Group B will receive topical application of titania nanoparticle infused fluoride varnish for antiplaque effects.Plaque will be assessed quantitatively by modified plaque index.

Timeline

• Start date: 2025-11-01
• Primary completion: 2027-07-01
• Completion: 2027-12-01
• First posted: 2025-09-18
• Last updated: 2025-09-25

Locations

1 site across 1 country: Pakistan