NCT07178262

Erector Spinae Block in Reducing Peri-operative Opioid Consumption in Total Abdominal Hystrectomy

Opioid Sparing Effect of Erector Spinae Block in Patients Undergoing Total Abdominal Hysterectomy; A Randomized Control Trial

• Status: Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Kulsoom International Hospital · Academic / Other
• Sex: Female
• Age: 16 Years – 80 Years
• Healthy volunteers: Accepted

Summary

Hystrectomy is a surgical procedure that involves removal of uterus from the body of patient using a lower abdominal incision. This is an extremely painful procedure which causes discomfort and greatly increases opioids consumption in the peri-operative period. This can be reduced by using nerve blocks such as Erector spinae plane block.

Detailed description

Total abdominal hystrectomy is associated with significant pain due to large abdominal incision and significant surgical dissection. This greatly increases the consumption of Opioid in the peri-operative period. High dose opioid consumption is associated with constipation, nausea, vomiting and respiratory depression. This significantly hampers post operative recovery. Fascial plane blocks such as Erector spinae block provides significant analgesia greatly reducing opioid consumption and there by reducing the associated side effects.

Conditions

• Erector Spinae Block
• Enhanced Recovery After Surgery (ERAS) Protocol
• Opioid

Interventions

Type	Name	Description
DRUG	Erector Spinae (ESP) Block with Bupivacaine (Marcaine®)	Bilateral Erector Spinae Block at T10 level using 30ml of 0.25% Bupivacaine will be administered under Ultrasound guidance before surgical incision.
DRUG	Placebo	Bilateral Erector Spinae Block at T10 level using 30ml of Normal saline will be administered under Ultrasound guidance before surgical incision.

Timeline

• Start date: 2025-08-01
• Primary completion: 2025-10-30
• Completion: 2025-10-30
• First posted: 2025-09-17
• Last updated: 2025-09-17

Locations

1 site across 1 country: Pakistan

Regulatory

• FDA-regulated drug study